系統(tǒng)介紹
動(dòng)物精細(xì)行為分析系統(tǒng)是Gene&I聯(lián)合Cleversys推出的針對(duì)于復(fù)雜疾病表現(xiàn)進(jìn)行分析的展品，也是動(dòng)物行為分析的旗艦產(chǎn)品，代表了動(dòng)物行為分析的行業(yè)領(lǐng)先水平。
產(chǎn)品可自動(dòng)分析動(dòng)物日常行為的23種身體行為，并可將分析的行為進(jìn)行分類(lèi)統(tǒng)計(jì)。針對(duì)于帕金森、神經(jīng)性舞蹈癥、阿爾茲海默癥、瘋牛病等一些無(wú)法使用單一指標(biāo)進(jìn)行評(píng)價(jià)的疾病，可通過(guò)對(duì)動(dòng)物某一些身體行為異常改變的統(tǒng)計(jì)分析來(lái)進(jìn)行評(píng)價(jià)。
產(chǎn)品具有兩個(gè)版本。HomecageScan(CleverSys, Inc., CSI)是針對(duì)于大小鼠日常行為分析的版本；PrimateScan(CleverSys, Inc., CSI)是針對(duì)于靈長(zhǎng)類(lèi)動(dòng)物進(jìn)行日常行為分析的版本。
可分析動(dòng)物直立身體、回降身體、向左走、向右走、吃、喝、咀嚼、清理身體、排尿、垂直懸吊、偎著籠子懸吊、垂直降落、跳躍、轉(zhuǎn)動(dòng)、轉(zhuǎn)圈、睡覺(jué)、痙攣、覺(jué)醒、 挖掘找尋糧食、嗅、聞、間歇停頓 、伸懶腰等行為。
系統(tǒng)特點(diǎn)
● 全自動(dòng)動(dòng)物精細(xì)自然行為分析
● 晝夜節(jié)律分析
● 實(shí)時(shí)分析和回放分析兩種選擇
● 24小時(shí)以上連續(xù)攝像
● 具有雙擊活動(dòng)事件進(jìn)行事件發(fā)生視頻片段回放功能
● 實(shí)驗(yàn)過(guò)程中動(dòng)物行為詳細(xì)的統(tǒng)計(jì)信息
● 生物節(jié)律
● 神經(jīng)性舞蹈癥(Huntington Disease)
● Prion Disease
● 狂躁癥(Mania)
● 疾病過(guò)程觀察
● 遺傳研究
● 毒理學(xué)研究
● 進(jìn)食/飲水研究
● 肥胖/代謝疾病研究
● 慢性/自發(fā)疼痛研究
● 運(yùn)動(dòng)缺陷研究
● 衰老研究
Phenotypic arrays of HD and PrD behaviors over time. Meanvalues for HD(A) or PrD (B) were divided by mean control values to give the fold increase or decrease in the behaviors listed. The fold increase or decrease is indicated in the figure as increasing intensity of blue for negative fold changes or yellow for positive fold changes
Andrew D. Steele, Walker S. Jackson, Oliver D. King, and Susan Lindquist. The power of automated high-resolution behavior analysis revealed by its application to mouse models of Huntington's and prion diseases.
Reference
E.B. Adamah-Biassi, I. Stepien, R.L. Hudson, M.L. Dubocovich (2013), Automated Video Analysis System Reveals Distinct Diurnal Behaviors in C57BL/6 and C3H/HeN Mice, Behavioural Brain Research, Volume 243, 15 April 2013, Pages 306–312.
Miki Hiasa, Yumiko Isoda, Yasushi Kishimoto, Kenta Saitoh, Yasuaki Kimura, Motomu Kana, MasakatsuShibasaki, Dai Hatakeyama, Yutaka Kirino, Takashi Kuzuhara, (2013), Inhibition of monoamine oxidase A and stimulation of behavioural activities in mice by the inactive prodrug form of the anti-influenza agent oseltamivir, British Journal of Pharmacology, 2013.
Kyzar, M Pham, A Roth, J Cachat, J Green, S Gaikwad, and AV Kalueff, (2012) Alterations in grooming activity and syntax in heterozygous SERT and BDNF knockout mice: The utility of behavior-recognition tools to characterize mutant mouse phenotypes, Brain Res Bull, Dec 2012; 89(5-6): 168-76.
NC Lee, YD Shieh, YH Chien, KY Tzen, I Yu, PW Chen, (2012) Regulation of the dopaminergic system in a murine model of aromatic L-amino acid decarboxylase deficiency, Neurobiology of Disease, Available online 26 December 2012.
Yasushi Kishimoto, ErinaHigashihara,AkikoFukuta, Akira Nagao, Yutaka Kirino, (2012) Early impairment in a water-finding test in a longitudinal study of the Tg2576 mouse model of Alzheimer's disease, Brain Research, Available online 7 November 2012.
Gillian Hamilton and Thomas H. Gillingwater, (2012) Spinal muscular atrophy: going beyond the motor neuron, TRMOME-835; No. of Pages 11.
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